Edema and hemoconcentration in mice experimentally infected with Vibrio vulnificus

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Edema and hemoconcentration in mice experimentally infected with Vibrio vulnificus.

Vibrio vulnificus (lactose-positive Vibrio), a recently recognized pathogenic marine species, produced extreme hemoconcentration and death within 3 to 6 h after subcutaneous or intraperitoneal injection of 10(8) viable cells into mice; hemotocrit values approached 70% (normal, 45%). About 1 ml of edema fluid accumulated at the site of each subcutaneous injection, and locally increased vascular ...

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Vibrio vulnificus in Taiwan

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Previous work suggested that a metalloprotease, Vvp, may be a virulence factor of Vibrio vulnificus, which causes severe wound infection and septicemia in humans. To determine the role of Vvp in pathogenesis, we isolated an isogenic protease-deficient (PD) mutant of Vibrio vulnificus by in vivo allelic exchange. This PD mutant was as virulent as its parental strain in mice infected intraperiton...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1981

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.32.3.1193-1199.1981